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Novel Solution of Visualization-Based Minimally Invasive Treatment for Neurosurgery

Magnetic Resonance-guided Laser Ablation Therapy System

Precision Treatment for the Future

The Magnetic Resonance-guided Laser Ablation Therapy System, with the core of Magnetic Resonance-guided Laser Interstitial Thermal Therapy (MRgLITT), is a novel minimally invasive technique used to treat various intracranial conditions such as drug-resistant epilepsy, brain metastases, gliomas, and radiation necrosis. The system involves placing a fiber optic probe into the lesion site, and controlled heating of the surrounding tissue through laser energy to induce thermal damage. Real-time magnetic resonance imaging is used for temperature monitoring, allowing continuous monitoring of the ablation zone and the ability to stop the procedure at any time.

Core Technological Principle

Biological Thermal Ablation Effect

LITT technology involves heating intracranial lesion tissues using lasers to achieve thermal ablation. When the temperature is below 43°C, there is no tissue damage. At 45-50°C, short-term reversible damage occurs, while prolonged exposure leads to irreversible damage. At 50-60°C, irreversible damage can be achieved within a few minutes. Temperatures between 60-90°C result in instantaneous cellular inactivation, achieving the desired therapeutic effect. Temperatures exceeding 100°C can cause intense vaporization, carbonization, or even melting. Therefore, during LITT procedures, real-time magnetic resonance guidance is used to control the core temperature of the ablation area within the range of 60-90°C, ensuring stable and controlled thermal ablation for therapeutic efficacy.

Scattered Beam Control

The magnetic resonance-guided laser ablation therapy system utilizes scattered fiber optic cables to deliver laser energy, enabling uniform ablation of the lesion. The scattered fiber optic cables are placed within a cooling sleeve, and a water cooling system is employed to ensure controlled core temperature.

Proton Resonance Thermometry

The LITT procedure is performed under real-time monitoring of magnetic resonance imaging (MRI). Protons at different temperatures exhibit varying distances of motion under MRI and can be scanned using specific imaging sequences. Through software algorithms, the protons' behavior is identified and processed in real-time, providing feedback to the user. The temperature measurement error is less than 1°C. This technology is internationally leading, with multiple invention patents and complete intellectual property rights.

Biological Thermal Ablation Effect

Scattered Beam Control

Proton Resonance Thermometry

Procedure Process

The LITT procedure begins with detailed surgical planning, including determining the placement of the fiber optic and the anticipated ablation range. Guided by a stereotactic device, the fiber optic is then inserted into the skull. The patient is subsequently transferred to the MRI suite, where scanning and laser ablation take place. Under real-time MRI guidance, the temperature and ablation range of the target area are monitored, ensuring safe and precise completion of lesion ablation.